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We show that ibrutinib not only exhibits additive activity when combined with GPX4 inhibitors but also enhances ferroptosis sensitivity by reducing intracellular glutathione and downregulating GPX4 protein expression

Electrolyte changes, especially increased blood potassium levels, may affect heart rhythm, so electrocardiogram (ECG or EKG) is sometimes used to monitor for arrhythmia (Ferri 2014a)

Rev Environ Health 26(2):111118

Relapse can occur in up to 50 percent of patients who respond initially, regardless of the regimen used